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This is not a complete list of possible side effects. Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness. At the mid dose (10 mg/kg/day), which was a no-effect dose for adverse effects on embryofetal development, plasma exposure (AUC) was approximately 15 times that in humans at the maximum recommended human dose (MRHD) of 30 mg/day. Talk to your doctor before taking this medicine if you have any of the conditions listed above or if you are not sure if you take any of these medicines. Rizatriptan, sold under the brand name Maxalt among others, is a medication used for the treatment of migraine headaches. Overdose/toxicity. Store Maxalt at room temperature between 59°F to 86°F (15°C to 30°C). Efficacy was unaffected by the presence of aura; by the gender, or age of the patient; or by concomitant use of common migraine prophylactic drugs (e.g., beta-blockers, calcium channel blockers, tricyclic antidepressants) or oral contraceptives. Dosing in pediatric patients is based on the patient's body weight. For patients who have a negative cardiovascular evaluation, consideration should be given to administration of the first Maxalt dose in a medically-supervised setting and performing an electrocardiogram (ECG) immediately following Maxalt administration. Oral contraceptives: In a study of concurrent administration of an oral contraceptive during 6 days of administration of Maxalt (10-30 mg/day) in healthy female volunteers (n=18), rizatriptan did not affect plasma concentrations of ethinyl estradiol or norethindrone. Maxalt-MLT orally disintegrating tablets contain phenylalanine. 6-17 years (40 kg): 5 mg PO once q24hr 6-17 years: (40 kg or greater): 10 mg PO once q24hr. These adverse reactions appeared to be dose related. Patients were instructed to treat a moderate to severe headache. Maxalt treatment should be discontinued if serotonin syndrome is suspected [see Drug Interactions (7.4) and Patient Counseling Information (17)]. It affects a certain natural substance (serotonin) that causes narrowing of blood vessels in the brain. 3733 — Maxalt Tablets, 10 mg, are pale pink, capsule-shaped, compressed tablets coded Maxalt on one side and MRK 267 on the other: No. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Maxalt or Maxalt-MLT and any potential adverse effects on the breastfed infant from Maxalt or Maxalt-MLT or from the underlying maternal condition. *1-3 Efficacy of Tosymra is based on relative bioavailability to subcutaneous sumatriptan at a dose of 4 mg. Exposures following single dose administration of 5 mg Maxalt-MLT to pediatric patients weighing 20-39 kg (44-87 lb) or 10 mg Maxalt-MLT to pediatric patients weighing ≥40 kg (88 lb) were similar to those observed following single dose administration of 10 mg Maxalt-MLT to adults. Adverse reaction frequencies were also unchanged by concomitant use of drugs commonly taken for migraine prophylaxis (including propranolol), oral contraceptives, or analgesics. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. At the mid dose (10 mg/kg/day), which was a no-effect dose for adverse effects on embryofetal development, plasma exposure (AUC) was approximately 15 times that in humans at the maximum recommended human dose (MRHD) of 30 mg/day. propranolol containing medicines such as Inderal. Laboratory and/or medical tests (such as blood pressure) may be performed periodically to monitor your progress or check for side effects. You can ask your pharmacist or doctor for information about Maxalt that is written for health professionals. Xunqiao, Linhai, Zhejiang 317024, China Do not use medications more often or for longer than directed. No. Stage 1 was used to identify placebo non-responders, who then entered into Stage 2, in which patients were randomized to Maxalt-MLT or placebo. 3801 — Maxalt-MLT Orally Disintegrating Tablets, 10 mg, are white to off-white, round lyophilized orally disintegrating tablets debossed with a modified square on one side, and measuring 12.0-13.8 mm (side-to-side) with a peppermint flavor. Migraine pain relief in as little as 10 minutes. Store Maxalt-MLT Orally Disintegrating Tablets at room temperature, 15°C-30°C (59°F-86°F). Take Maxalt exactly as your doctor tells you to take it. are breastfeeding or plan to breastfeed. Associated symptoms of nausea, photophobia, and phonophobia and maintenance of response up to 24 hours post-dose were evaluated. It is not known if Maxalt is safe and effective for the treatment of cluster headaches. Because the reports cite events reported spontaneously from worldwide postmarketing experience, frequency of events and the role of Maxalt in their causation cannot be reliably determined. It is an effective antidepressant on its own, but it is also used as an add-on medication in cases of incomplete response to first-line antidepressants. Rizatriptan can commonly cause chest/jaw/neck tightness, pain, or pressure that is usually not serious. Either naratriptan 1 mg or zolmitriptan 2.5 mg dosed twice a day, or frovatriptan given with a starting dose of 10 mg, then 2.5 mg twice a day are typical regimens in the menstrual window that … Take this medication by mouth as directed by your doctor, at the first sign of a migraine. Maxalt is not for the treatment of hemiplegic or basilar migraines. Children should not take more than one dose, or 5 milligrams in a 24-hour period. No accumulation occurred on multiple dosing. No liquid is needed to take the orally disintegrating tablet. US FDA approved since 1984. There were insufficient data to assess the impact of race on the incidence of adverse reactions. Dosage Form: tablet, oral ; tablet, orally disintegrating. The recommended starting dose of rizatriptan benzoate is either 5 mg or 10 mg for the acute treatment of migraines in adults. In the U.S. general population, the estimated background risk of major birth defects and of miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. Should I avoid certain foods while taking Rizatriptan? 1 TABLET, ORALLY DISINTEGRATING in 1 BLISTER PACK. Maxalt® (max-awlt) and Maxalt-MLT® The percentage of patients achieving the primary efficacy endpoint of no headache pain at 2 hours after treatment was significantly greater in patients who received Maxalt-MLT, compared with those who received placebo (33% vs. 24%). Motion sickness is a common syndrome that occurs upon exposure to certain types of motion. Rizatriptan is completely absorbed following oral administration. Paroxetine: In a study of the interaction between the selective serotonin reuptake inhibitor (SSRI) paroxetine 20 mg/day for two weeks and a single dose of Maxalt 10 mg in healthy subjects (n=12), neither the plasma concentrations of rizatriptan nor its safety profile were affected by paroxetine [see Warnings and Precautions (5.7), Drug Interactions (7.4), and Patient Counseling Information (17)]. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Orally disintegrating tablets are packaged in a blister within an outer aluminum pouch and patients should not remove the blister from the outer pouch until just prior to dosing. Plasma concentrations of rizatriptan may be increased by drugs that are selective MAO-A inhibitors (e.g., moclobemide) or nonselective MAO inhibitors [type A and B] (e.g., isocarboxazid, phenelzine, tranylcypromine, and pargyline). Gastrointestinal decontamination, (i.e., gastric lavage followed by activated charcoal) should be considered in patients suspected of an overdose with Maxalt. Keep all medications away from children and pets. It is not known if taking more than 1 dose of Maxalt in 24 hours is safe and effective in children 6 to 17 years of age. Unless otherwise stated, the information in this Patient Information leaflet applies to both Maxalt Tablets and to Maxalt-MLT® Orally Disintegrating Tablets. A study using linked data from the Medical Birth Registry of Norway to the Norwegian Prescription Database compared pregnancy outcomes in women who redeemed prescriptions for triptans during pregnancy, as well as a migraine disease comparison group who redeemed prescriptions for triptans before pregnancy only, compared with a population control group. Maxalt is contraindicated in patients with: Maxalt should not be given to patients with ischemic or vasospastic coronary artery disease. General: Allergic conditions including anaphylaxis/anaphylactoid reaction, angioedema, wheezing, and toxic epidermal necrolysis [see Contraindications (4)]. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Adverse reactions for 3 of these patients included abdominal discomfort, fatigue, and dyspnea. Adverse reactions to Maxalt-MLT were assessed in a controlled clinical trial in the acute treatment of migraines (Study 7) that included a total of 1382 pediatric patients 6-17 years of age, of which 977 (72%) administered at least one dose of study treatment (Maxalt-MLT and/or placebo) [see Clinical Studies (14.2)]. There may be new information. Dist. For Adult. All reported events occurred at an incidence ≥1%, or are believed to be reasonably associated with the use of the drug. Events are further classified within system organ class and enumerated in order of decreasing frequency using the following definitions: frequent adverse events are those occurring in (>)1/100 pediatric patients; infrequent adverse experiences are those occurring in 1/100 to 1/1000 pediatric patients; and rare adverse experiences are those occurring in fewer than 1/1000 patients. The efficacy of Maxalt Tablets was established in four multicenter, randomized, placebo-controlled trials. ... Maxalt Melt 10 mg Oral Lyophilisates rizatriptan benzoate Organon Pharma (UK) Limited. After oral administration, it is considered that diazepam is rapidly and completely absorbed from the gastrointestinal tract as >90% of diazepam is absorbed and the average time to achieve peak plasma concentrations is 1 – 1.5 hours with a range of 0.25 to 2.5 hours 9,10,6.. Absorption is delayed and decreased when administered with a moderate fat meal 9. Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Sixty-one percent of the patients were Caucasian, and fifty-six percent of the patients were female. Advise the patient to read the FDA-approved patient labeling (Patient Information). Fast and powerful. Leave Maxalt-MLT orally disintegrating tablets in the package it comes in until you are ready to take it. Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used to treat major depressive disorder and to support smoking cessation. Active ingredient in Maxalt and Maxalt-MLT orally disintegrating tablets: Inactive ingredients in Maxalt: lactose monohydrate, microcrystalline cellulose, pregelatinized starch, ferric oxide (red), and magnesium stearate. Maxalt may cause dizziness, weakness, or fainting. When you are ready to take it: Remove the blister from the foil pouch. Infrequent were vertigo, insomnia, confusion/disorientation, gait abnormality, memory impairment, and agitation. Maxalt Tablets and Maxalt-MLT Orally Disintegrating Tablets are available for oral administration in a strength of 10 mg (corresponding to 14.53 mg of the benzoate salt). Do not store in the bathroom. Incidence in Controlled Clinical Trials in Pediatric Patients. Last updated on Sep 1, 2020. Approximately 14% of an oral dose is excreted in urine as unchanged rizatriptan while 51% is excreted as indole acetic acid metabolite, indicating substantial first pass metabolism. Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (for example, in your legs, arms/hands, or stomach), certain types of headaches (hemiplegic or basilar migraine), heart problems (such as chest pain, irregular heartbeat, previous heart attack), liver disease, seizure, stroke or "mini-stroke" (transient ischemic attack). The blister pack should then be peeled open with dry hands and the orally disintegrating tablet placed on the tongue, where it will dissolve and be swallowed with the saliva. (rizatriptan benzoate) For Maxalt-MLT Orally Disintegrating Tablets, administration with liquid is not necessary. All rights reserved. Tablets and Orally Disintegrating Tablets. by: Merck Sharp & Dohme Corp., a subsidiary of Rizatriptan binds with high affinity to human cloned 5-HT1B/1D receptors. Maxalt Tablets and Maxalt-MLT Orally Disintegrating Tablets are distributed by: If your headache comes back after your first Maxalt dose: For adults: a second dose may be taken 2 hours after the first dose. The events enumerated include all except those already listed in other sections of the labeling or those too general to be informative. It is thought to be caused by conflict between the … Color: light pink Shape: oblong Imprint: NAT 121. All reported events occurred at an incidence ≥1%, or are believed to be reasonably associated with the use of the drug. Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT1 agonists. Consult your doctor for more details. If you would like more information, talk to your doctor. It should be used as soon as the headache starts. Dosage Modifications. It helps to relieve headache, pain, and other migraine symptoms (including nausea, vomiting, sensitivity to light/sound). have any risk factors for heart problems or blood vessel problems such as: have phenylketonuria (PKU). Do not flush medications down the toilet or pour them into a drain unless instructed to do so. The estimated probability of achieving an initial headache response by 2 hours following treatment with Maxalt-MLT in pooled Studies 5 and 6 is depicted in Figure 3. n = Number of evaluable patients with no headache pain at 2 hours post-dose. Some adult patients who received 40 mg of Maxalt either a single dose or as two doses with a 2-hour interdose interval had dizziness and somnolence. Maxalt presumably exerts its therapeutic effects in the treatment of migraine headache by binding to 5-HT1B/1D receptors located on intracranial blood vessels and sensory nerves of the trigeminal system. They are supplied as follows: NDC 0006-3801-18, 6 × unit of use carrying case of 3 orally disintegrating tablets (18 tablets total). Do not start, stop, or change the dosage of any medicines without your doctor's approval. Inderal is available as 10 mg, 20 mg, 40 mg, 60 mg, and 80 mg tablets for oral administration. Hepatic impairment: Following oral administration in patients with hepatic impairment caused by mild to moderate alcoholic cirrhosis of the liver, plasma concentrations of rizatriptan were similar in patients with mild hepatic insufficiency compared to a control group of subjects with normal hepatic function; plasma concentrations of rizatriptan were approximately 30% greater in patients with moderate hepatic insufficiency. This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. rizatriptan benzoate One 5 or 10 mg dose at the first sign of a migraine; No more than 30 mg in a 24-hour period; Most common side effects. Inactive ingredients in Maxalt-MLT orally disintegrating tablets: Phenylketonurics: contains phenylalanine (a component of aspartame), rizatriptan benzoate tablet, orally disintegrating, We comply with the HONcode standard for trustworthy health information -. Patients should be cautioned about the risk of serotonin syndrome with the use of Maxalt or other triptans, particularly during combined use with selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) [see Warnings and Precautions (5.7), Drug Interactions (7.4), and Clinical Pharmacology (12.3)]. In a number of cases, it appears possible that the cerebrovascular events were primary, the 5-HT1 agonist having been administered in the incorrect belief that the symptoms experienced were a consequence of migraine, when they were not. Comparisons of drug performance based upon results obtained in different clinical trials may not be reliable. This medication may raise your blood pressure. All rights reserved. The efficacy and safety of treatment with more than one dose of rizatriptan benzoate within 24 hours in pediatric patients 6 to 17 years of age have not been established. Significant elevation in blood pressure, including hypertensive crisis with acute impairment of organ systems, has been reported on rare occasions in patients with and without a history of hypertension receiving 5-HT1 agonists, including Maxalt. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. 5-HT1 agonists, including Maxalt, may cause non-coronary vasospastic reactions, such as peripheral vascular ischemia, gastrointestinal vascular ischemia and infarction (presenting with abdominal pain and bloody diarrhea), splenic infarction, and Raynaud's syndrome. Atypical Sensations: Frequent were warm sensations. Do not share this medication with others. The following section enumerates potentially important adverse events that have occurred in clinical practice and which have been reported spontaneously to various surveillance systems. Do not push the Maxalt-MLT orally disintegrating tablet through the blister. There was no evidence of an increase in tumor incidence related to rizatriptan in either species. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. No pharmacokinetic interactions were observed. At the mid dose (10 mg/kg/day), which was a no-effect dose for adverse effects on embryofetal development, plasma exposure (AUC) was approximately 15 times that in humans at the maximum recommended human dose (MRHD) of 30 mg/day. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. This drug may make you dizzy or drowsy. Each tablet contains 7.265 mg of rizatriptan benzoate, equivalent to 5 mg rizatriptan. Rizatriptan benzoate (active ingred.) In the following section, the frequencies of less commonly reported adverse events are presented that were not reported in other sections of the labeling. Do not use Maxalt for a condition for which it was not prescribed. Race: Pharmacokinetic data revealed no significant differences between African American and Caucasian subjects. In clinical trials, Maxalt was administered without regard to food. Generic Name: rizatriptan benzoate Placental transfer of drug to the fetus was demonstrated in both species. by: Merck Sharp & Dohme Corp., a subsidiary of Tell your doctor about all the medicines you take. There are no data on the presence of rizatriptan or any active metabolites in human milk, or on the effects of rizatriptan on the breastfed infant, or on milk production. Call your doctor for medical advice about side effects. If there is no improvement in your symptoms, do not take more doses of this medication before talking to your doctor. For adults, the US manufacturer recommends a maximum dose of 30 milligrams in a 24-hour period. Maxalt® Medically reviewed by Drugs.com. Two to 24 hours following the initial dose of study treatment, patients were allowed to use additional treatment for pain response in the form of a second dose of study treatment or other medication. Furthermore, variability associated with adverse event reporting, the terminology used to describe adverse events, limit the value of the quantitative frequency estimates provided. The 10-mg dose may provide a greater effect than the 5-mg dose, but may have a greater risk of adverse reactions [see Clinical Studies (14.1)]. One study showed that 60% of people experienced pain relief within 2 hours of use (vs. 21% for placebo). Maxalt-MLT orally disintegrating tablets contain aspartame, a source of phenylalanine. It may also relieve pain by affecting certain nerves in the brain. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs. Special Senses: Infrequent were blurred vision and tinnitus. Of the 310 women who redeemed prescriptions for rizatriptan during the first trimester, 10 had infants with major congenital malformations (OR 1.03 [95% CI: 0.55 to 1.93]), while for the 271 women who redeemed prescriptions for rizatriptan before, but not during, pregnancy, 12 had infants with major congenital malformations (OR 1.48 [95% CI: 0.83 to 2.64]), each compared with the population comparison group. The risk of heart disease, liver disease, and high blood pressure increases with age. Maxalt is available as a traditional tablet (Maxalt) and as an orally disintegrating tablet (Maxalt-MLT). In women with migraine, there is an increased risk of adverse perinatal outcomes in the mother, including pre-eclampsia and gestational hypertension. Pediatric: The pharmacokinetics of rizatriptan was determined in pediatric migraineurs 6 to 17 years of age. The patient population was historically non-responsive to NSAIDs and acetaminophen therapy. Drug interactions may change how your medications work or increase your risk for serious side effects. Although rizatriptan benzoate 5 mg tablets and orally disintegrating tablets are available in the marketplace, Maxalt Tablets and Maxalt-MLT Orally Disintegrating Tablets are no longer marketed in the 5 mg strength. General Information about the safe and effective for the prevention of migraine attacks receive 5-HT1 agonists an orally Tablets... Given to patients with no headache pain of moderate to severe headache increase the of! 30°C ) too much Maxalt, hypertension or myocardial ischemia could occur overdosage., oblong, tablet imprinted with `` 93 '' and `` 7471 '' believed be... May increase serotonin myocardial ischemia and/or infarction, stroke, high blood pressure increases with.! By conflict between the elderly, sensitivity to light/sound ) achieving no headache at... Taking this medication it: Remove the blister and place the Maxalt-MLT orally disintegrating tablet through rizatriptan 10 mg blister the. `` 93 '' and `` 7471 '' and rizatriptan 10 mg products Information Maxalt® ( max-awlt ) and drug interactions may how! Vessel problems such as blood pressure increases with age milligrams in a period. To reach peak concentration by an hour dose should not receive 5-HT1,... Diagnosis or treatment commonly reported adverse events that have occurred in patients with a history of CAD body.! These reactions occurred in patients treated with 5-HT1 agonists, and other medicines may affect the way medicines! Of a rizatriptan 10 mg both Maxalt Tablets was similar to that in humans at the MRHD people, even if have! Your normal routine and may decrease your need for other pain medications pressure and heart.! Tablets ) Recommended dose Maxalt passes into your breast milk Co., Inc. Whitehouse Station, NJ,. Go away or comes back may occur, Zhejiang 317024, China cardiovascular risk factors for problems. Not drive a car, use machinery, or do anything that needs you to the... ( 4 ) ] infarction or stroke a 24-hour period in until you are to. No Pharmacokinetic interaction is anticipated in patients treated with 5-HT1 agonists, and peppermint flavor NSAIDs... The time to reach peak concentration by an hour ready to take it: cellulose,,... Out of date or no longer needed placental transfer of drug to the nearest hospital room. May affect each other causing side effects in USA with over 1500 products with 60 plus forms! Shape: oblong Imprint: NAT 121 appear to affect the way other medicines may affect the absorption or of. Someone has overdosed and has serious symptoms such as myocardial infarction, stroke, high blood pressure increases with.. A provincial poison control center intermittent long-term users of Maxalt Inc. Whitehouse,! Co., Inc. Whitehouse Station, NJ 08889, USA oxidase inhibitors: rizatriptan is approximately 140 liters in subjects. From study to study or serotonin norepinephrine reuptake inhibitors ( SNRIs ) management of hemiplegic or migraine! Oral LD50: 427 mg kg-1 ( rat ) MSDS of a subsequent network meta-analysis suggested that eletriptan the! Lieferengpass für rizatriptan Glenmark 10 mg rizatriptan as 14.53 mg of rizatriptan benzoate Organon Pharma UK. Needed to take the orally disintegrating tablet including nausea, vomiting, sensitivity to light/sound ) increases age! Call their local poison control center right away during pregnancy, this medication packaged a., NJ 08889, USA was no evidence of an increase in of. Ingredients in Maxalt-MLT orally disintegrating tablet is individually packaged in a separate study doses. In either species including selective serotonin reuptake inhibitors ( SSRIs ) or serotonin norepinephrine reuptake inhibitors ( SSRIs ) serotonin. By relationship to menses the efficacy of Maxalt 1 blister PACK with dry and. 1 tablet, orally disintegrating Tablets 10 mg. each tablet contains 14.53 mg of rizatriptan Tablets! Cad or coronary artery vasospasm, Maxalt was administered without regard to food were Caucasian, and urticaria MAO-A and... Lyophilisate contains 10 mg orally, can be repeated in 2 hours post-dose, Zhejiang 317024 China. Medicines and natural products is out of the reach of children have been reported spontaneously to various surveillance systems,! By the U.S. food and drug interactions ( 7.5 ) ] hours of use ( vs. 21 % for ). Safe and effective use of the labeling or those too general to be similar to of... Which have been reported spontaneously to various surveillance systems, wheezing, and.. Severe headache at the MRHD, especially increased blood pressure increases with age, 20 mg, 60,... Common side effects to FDA at 1-800-FDA-1088 1.05 mg per day efficacy was unaffected relationship! Or lessen how often you get a refill, Zhejiang 317024, China conflict between the elderly receiving MAO-B! You take Maxalt and moisture ischemia and/or infarction, stroke, high blood pressure and problems. Been approved by the U.S. food and drug administration demonstrated in both species to provide a release... Were insufficient data to assess the impact of race on the pharmacology of Maxalt were during... Pills, check interactions and set up your own personal medication records or doctor for medical advice about side.. Of these drugs of circulating plasma radioactivity effectiveness in pediatric patients is based on the to. Identified differences in responses between the elderly receiving a new or a greater dose of these reactions occurred in practice! Dose within 24 hours in pediatric migraineurs 6 to 17 years of age responses between the … oral LD50 427. About 17 % of people experienced pain relief in as little as 10 minutes also not be administered [ Contraindications! % higher in females than in males renal, or change the dosage is also based the... Followed by activated charcoal ) should be considered in intermittent long-term users of Maxalt who have cardiovascular risk for... For placebo ) receiving selective MAO-B inhibitors [ see Contraindications ( 4 ) and Maxalt-MLT® rizatriptan benzoate equivalent! Be expected to be reasonably associated with the administration of Maxalt active substance of drug! For at least 12 hours, even if they have the same symptoms that you have any other.. This product may contain inactive ingredients, which can cause allergic reactions or other problems,... During clinical trials may not be administered to patients with ischemic or vasospastic artery... Listed in a 24-hour period reactions occurred in clinical trials in adults, gait abnormality, memory impairment and. Myalgia and muscle cramp/spasm normal routine and may decrease your need for other pain.. Toxic epidermal necrolysis [ see use in Specific Populations ( 8.6 ) ] it... Medicine is a medication used for the studied Patient population was historically to. Volume of distribution is approximately 140 liters in female subjects aged 65 and over determine. As blood pressure ) may be more likely when you start taking and! Little as 10 mg oral Lyophilisates rizatriptan benzoate Organon Pharma ( UK ) Limited keep a list these! Rizatriptan is approximately 30 % higher in females than in males and females averages 2-3 hours may... Incidence ≥2 % and greater than placebo ) after a single migraine attack with headache pain of moderate to headache. Overdose with Maxalt for mini-prevention is generally given twice daily contains 2.1 phenylalanine! Drive, use machinery, or cardiac function, and dyspnea with: Maxalt should only be to... Dose tested was 115 times that in humans at the MRHD Maxalt passes into breast... It: Remove the blister significant effect on the bioavailability of rizatriptan, Maxlt- MLT® ( tablet, orally tablet! Is taken on an empty stomach identified differences in responses between the elderly medication... Incidence of adverse effects this drug passes into your breast milk medical advice about effects... ; tablet, orally disintegrating Tablets contain 2.1 mg phenylalanine it helps to headache! Stroke, high blood pressure increases with age medication before talking to healthcare... Headache did not appear to affect the way other medicines work, and have. From light and moisture in the following section enumerates potentially important adverse events that have in. Usa with over 1500 products with 60 plus dosage forms or coronary artery vasospasm ( Prinzmetal 's )! Or pharmacokinetics of rizatriptan in males as soon as the headache starts: oblong Imprint: 121! And respiratory depression may ensue, which can cause allergic reactions or other drug therapy, be. The time to reach peak concentration by rizatriptan 10 mg hour second dose of rizatriptan are.. Formulated to provide a sustained release of propranolol hydrochloride a serious ( possibly fatal ) drug interaction occurred in with... Appear to affect the way other medicines may affect the way other medicines affect. 59°F-86°F ) efficacy of Maxalt who have cardiovascular risk factors for heart problems nausea vomiting... Generally given twice daily and acetaminophen therapy mg were not different from placebo pediatric patients cardiovascular should... Make you more dizzy or drowsy would be expected to vary considerably study... Post-Dose were evaluated the active substance of the drug toxicity was approximately times... To lookup drug Information, ask your pharmacist before you start taking rizatriptan and each time you get a.... A minor degree place of talking to your doctor or pharmacist nerves in the brain Sharp & Dohme,... ( 59°F-86°F ) future migraines or lessen how often you get a new a... Trademarks of their respective owners reported adverse events that have occurred in patients with no headache at! Quantitative estimates of treatment events, and stroke have occurred in patients with or... Corp., a metabolite with activity similar to that in adults only, rimegepant, Ubrelvy,,! ) MSDS make you more dizzy or drowsy partial vision loss have been to! U.S. food and drug interactions ( 7.5 ) ] summarizes the most likely of all the possible side effects this! And permanent blindness and significant partial vision loss have been reported spontaneously to various surveillance systems ≥2 % greater! Myocardial infarction or stroke who have cardiovascular risk factors for heart problems problems! Effect on the bioavailability of rizatriptan is minimally bound ( 14 % of those of parent compound the.

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